Methodology
What this site reads, how often, what a machine decided versus what a person decided, and — most importantly — what it is not able to tell you.
1 source is not reporting cleanly — changes may be missingeuropepmc STALE
Changes that would have come from the sources below are absent from this feed. Absence here means “not observed”, not “did not happen”.
- Europe PMC (
europepmc, daily) — last successful fetch (2 days ago), last run statusok— past its staleness threshold.
What this site cannot tell you
Registry and filing data lag reality. A trial can stop enrolling, change its endpoints, or be abandoned months before the sponsor updates the registry record — registry updates are an administrative act, not an event feed. A corporate decision typically predates the filing that reveals it by a quarter or more. Every date on this site is the date something was recorded or detected, never the date it happened.
The absence of a change event is not evidence that nothing changed. A quiet feed and a broken fetcher look identical from the outside, and so do a quiet feed and an event that no source has published yet. There are at least four reasons a real change can be missing here: the source has not published it, the source published it in a field or document that is not tracked, the fetch failed, or the change happened somewhere no source covers at all — private companies, unregistered preclinical work, and unannounced internal decisions.
This is why per-source fetch health is on every page, and why an empty feed here is always rendered as“no changes detected since X, from sources last checked at Y” rather than as “nothing happened”.
Nothing here is medical, investment, or regulatory advice, and no entry is a claim about a drug's safety or efficacy. Follow the source link and read the primary record.
Sources and update cadence
| Source | Cadence | Last success | Status | Records | What is read | What it cannot see |
|---|---|---|---|---|---|---|
ClinicalTrials.govctgov | nightly | today | ok | 245 | Full study records for every tracked NCT id, plus sponsor- and intervention-scoped searches for discovery. Status, phase, enrolment, dates, why-stopped. | Free-text search is imprecise enough to be unsafe on its own — a term search for one sponsor returned five studies, none of them theirs — so search output never feeds the tracked set directly. Tracked ids are also polled individually, because an edit can drop a study out of a search result set entirely. |
SEC EDGARedgar | weekly | yesterday | ok | 76 | Filing index per tracked public sponsor, and the text of the “About [Company]” paragraph extracted from 8-K exhibits. Diffs of that paragraph are the highest-value corporate signal here. | Only public companies file. Academic sponsors, private companies and foreign subsidiaries are invisible to this source. Not every 8-K carries an exhibit, and HTML-to-text extraction has its own false-diff modes that have to be normalised away. |
Europe PMCeuropepmc | daily | 2 days ago | stale | 3,823 | New and updated publications matching tracked therapeutics, mechanisms and APOE variants; DOI/PMID linkage. | Indexing lags publication, and publication lags the work by months to years. A preclinical program can be years old before anything is indexed. |
OpenAlexopenalex | weekly | yesterday | ok | 48,888 | Citation graph and author/affiliation linkage across tracked publications. | Used for linkage, not discovery. Several of its record fields drift continuously and are stripped before change detection, or every record would report a change on every run. |
openFDAopenfda | weekly | yesterday | ok | 6 | Label text for approved therapeutics — boxed warnings, APOE4 genotyping guidance, genotype-stratified ARIA frequency tables, dosing sections. | Only covers approved products, so it is silent for every investigational therapeutic. Label revisions appear in the API some time after they take effect. |
Press releases (RSS)rss | hourly | yesterday | ok | 155 | Sponsor investor-relations feeds and newswire topic feeds. Lowest latency of any source here. | Entirely unstructured and promotional. Feeds an extraction layer for candidate signals; it never writes to the canonical record directly, and nothing from it is treated as fact without a second source. |
Automated versus curated
Automated — no human in the loop
- Fetching every source on the cadence above, and recording each run's outcome.
- Canonicalising each payload and hashing it. Fields that churn without the underlying record changing — global data-release dates, citation counts, indexing timestamps — are stripped before hashing. Left in, they would fabricate a change event for every record on every run and drown the real signal.
- Detecting field-level differences against the previous observed state and emitting a change event. Detection compares content hashes, not insert success, so a value that flips
A → B → Ais still recorded as two changes. - An initial significance score, from the field that changed and the direction of the change.
Curated — a person decided
- Which therapeutics are tracked at all, and the mechanism class each belongs to.
- The trial allowlist for the approved anti-amyloid antibodies. Registry search for those returns 100+ studies dominated by third-party work; the tracked set is a human-maintained list of NCT ids, versioned in the repo, so every addition is itself reviewable.
- Every editorial summary attached to a change, and the notes on each therapeutic page.
- Confirmation or correction of the automated significance score. 0 of the 230 changes in this snapshot have been reviewed; the rest are labelled unreviewed in the feed and carry only the machine's judgement.
How significance is used
Significance describes how much a change should move your reading of a program — not how important the program is.
- High
- 0 in this snapshot. A change to the state of the program: trial termination or withdrawal, a sponsor dropping a therapeutic from its corporate description, a label change to genotype-conditioned guidance, a sponsor handoff.
- Medium
- 3 in this snapshot. A change to expectations rather than state: date slips, status transitions along the normal lifecycle, results posting, a first peer-reviewed report.
- Low
- 227 in this snapshot. Administrative motion — enrolment adjustments, routine filings, record touch-ups. Recorded for completeness and to make the diff auditable; usually not worth reading.
Confidence on a therapeutic
curated means identity, sponsor and mechanism have been verified by a person against primary sources. provisional means at least one of those is unresolved — a program known from an abstract or a patent, with no registry entry to anchor it. Provisional records are shown, and labelled, rather than hidden: a provisional program resurfacing is exactly the event worth catching.
Coverage
12 therapeutics are tracked. The scope is APOE-directed therapeutics plus APOE-conditioned ones — the approved anti-amyloid antibodies are included not because they target APOE but because APOE4 genotype determines their testing requirements and their ARIA risk.
How this page is built
Ingestion runs on a private host next to its database. A publish step queries that database, writes a JSON snapshot, and the site is built statically from it. There is no database behind this site, no API, and no client-side data fetching — what you are reading is a build artifact of the snapshot taken .
That design has one specific failure mode, and it is worth stating plainly: if the publish step fails, this site keeps serving the previous snapshot indefinitely, and every page will look exactly as it does now. The defence is that the snapshot carries its own generation time and per-source fetch health, and every page renders both — so a stale site displays a stale timestamp instead of looking current. If the snapshot time at the top of this page is old, the data is old, regardless of how the rest of the page reads.